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高、低度胶质瘤的脑定位和肿瘤生物学标志物

编辑:INC|发布时间:2020-12-25 13:11|点击次数:
最近的研究表明胶质瘤的位置可能与特定的生物学特征有关。我们的目的是探讨MGMT定位状态和Ki67阳性与患者年龄、胶质瘤位置和偏侧性的关系...

  Brain location and tumor biological markers in high and low grade gliomas: our experience

  Abstract

  Background: Recent studies suggest gliomas location may be correlated with specific biological signatures. Our purpose was to focus on the possible correlation between MGMT metilation status and Ki67 positivity with patient age, glioma location and lateralization.

  摘要

  背景:最近的研究表明胶质瘤的位置可能与特定的生物学特征有关。我们的目的是探讨MGMT定位状态和Ki67阳性与患者年龄、胶质瘤位置和偏侧性的关系。

  Methods: We performed a retrospective evaluation to assess the correlation between MGMT metilation status and Ki67 index positivity with patient age, glioma location and lateralization.

  方法:采用回顾性分析的方法,评价MGMT检测状态和Ki67指数阳性率与患者年龄、胶质瘤位置及偏侧性的关系。

  Results: The study included 174 supratentorial gliomas. Of these, 144 tumors were high grade gliomas (HGGs) and 30 tumors were low grade gliomas (LGGs). In HGG group we detected an association between tumor location and MGMT status. Those GBMs located in the frontal lobe were significantly associated with MGMT methylated status (MGMT+) and Ki67<30% than those GBMs located in other sites; while those GBMs located in the temporal lobe were associated with MGMT unmethylated (MGMT-) status. In anaplastic gliomas, we found an association between the involvement of the frontal lobe with MGMT+ status and Ki67<30%. In LGG group, our results showed that both frontal and temporal lobe were associated with a Ki67<30% and there was a predictive value for MGMT methylation status when patient age increased.

  结果:本研究包括174例幕上胶质瘤。其中高级别胶质瘤144例,低度胶质瘤30例。在HGG组,我们检测到肿瘤位置与MGMT状态之间的关联。位于额叶的GBMs与MGMT甲基化状态(MGMT+)显著相关,Ki67<30%,而位于颞叶的GBMs与MGMT非甲基化(MGMT-)状态相关。在间变性胶质瘤中,我们发现额叶受累与MGMT+状态和Ki67<30%有关。在LGG组,我们的结果显示额叶和颞叶的Ki67<30%相关,并且当患者年龄增加时,MGMT甲基化状态有预测价值。

  Conclusions: Our findings suggest there is a high variability in anatomical distribution of biological glioma markers and this high heterogeneity may have a clinical role. Moreover our study supports the idea that frontal lobe HGGs may be biologically favorable. Considering that as all glioma with lobar location are more amenable to radical surgical resection, it may be assumed that frontal tumor can have a better prognosis, and we have shown, to our knowledge for the first time, this is true both for HGG and for LGG.

  结论:我们的发现提示胶质瘤生物标记物的解剖分布具有高度的变异性,这种高度的异质性可能具有临床意义。此外,我们的研究支持额叶HGGs在生物学上是有利的。考虑到所有具有叶部位置的胶质瘤更容易接受根治性手术切除,因此可以认为额叶肿瘤的预后更好,而且我们首次证明,就我们所知,这对HGG和LGG都是正确的。

  原文链接:http://npub.ltlogo.top/33332981/

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